… chemotherapy of either oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) or irinotecan, …
in metastatic colorectal cancer than erlotinib and gefitinib, as recently a pre-clinical study also …

… in combination with 5-fluorouracil, folinic acid and irinotecan (… with 5-fluorouracil, oxaliplatin,
leucovorin and irinotecan (… ADJUVANT clinical trial (“Methods”), which explored gefitinib in …

… patients treated with cetuximab in combination with FOLFIRI (irinotecan, 5-fluorouracil, and
leucovorin… We retrospectively analyzed one clinical trial involving two treatment arms and 667 …

… FOLFIRI regimen (leucovorin, fluorouracil and irinotecan) and … a day) or 5-fluorouracil (425
mg/m 2 ) with leucovorin (20 mg/… assessing the effectiveness and safety of gefitinib (250 mg) …

… efficacy against colorectal cancer was 5-fluorouracil [11]. … with bolus 5-FU (irinotecan, bolus
5-FU, and leucovorin [IFL]), … The most significant inhibitors of EGRF are erlotinib and gefitinib (…

… a combination of 5-fluorouracil/leucovorin (5-FU/LV) and irinotecan. Thirteen (12%) received
… phase II study enrolling mCRC patients with acquired irinotecan resistance (the patients …

… Cisplatin and 5-fluorouracil have been considered standard … Negative results from Phase
3 trials testing gefitinib and … Combinations of irinotecan with other cytotoxic agents were …

… Gefitinib induces a cell cycle arrest in G1 phase with chronic administration and … S phase
such as irinotecan. For example, in a preclinical study in breast cancer of the effects of gefitinib, …

… gefitinib EGFR exon 19 deletion or exon 21 point mutation … CORRECT trial - a randomized
phase III study in patients with … Another issue arose when irinotecan or its active metabolite SN…

… of oxaliplatin with leucovorin and 5-fluorouracil showed a less … agents such as gefitinib,
bleomycin, and mitomycin [14]. In the … or FOLFIRI (5-fluorouracil, leucovorin, and irinotecan) and …